Synaptic circuit correlates of long-lasting behavioral changes in affective brain states.
Mission.
Our research goal is to understand the changes in synaptic connectivity that lead to long-lasting states of anxiety and depression. We are looking at synaptic connectivity on the single neuronal level with high throughput to resolve the connectome of entire brain regions. We identify key circuit motiifs in maladapted circuits of rodents by electric and molecular profiling. We are aiming to discover the key players of neuronal circuit maladaptation that leads to affective brain states in patients with anxiety or depression.
Approach.
To understand functional circuit architecture and the identity of its neurons, we develop interdisciplinary optical, molecular and computational methods and apply them to obtain a cohesive understanding of neuronal connectivity and its causal relation to behavior.
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